Anti-Aging Boost

From Garlic's Chemicals

From Garlic's Chemicals, Carmia Borek, Anti-Aging

From Garlic's Chemicals, Carmia Borek, Anti-Aging

The history of garlic as a remedy to prevent and combat disease goes back thousands of years. Modern medicine has confirmed that its remedial properties range from boosting immunity to cutting down the duration of a common cold or flu.

But while garlic is an excellent condiment, ingesting large amounts of fresh bulbs to achieve an immuno-boosting effect is not for everyone. Garlic’s strong odor lingers on the breath and skin and its consumption may lead to gastrointestinal problems including fatulence and diarrhea. The supplement aged garlic extract (AGE), which is odorless, is made from organically grown garlic, using a lengthy procedure of extraction and aging at room temperature. The process converts harsh volatile substances such as allicin to stable compounds and increases the antioxidant content above the levels found in fresh garlic. Today, much of the research on garlic’s ability to enhance cellular protection stems from studies using AGE.

Complex Antioxidant Mix

The major components of AGE are organosulfur compounds with antioxidant activity, largely water soluble, including highly bioavailable S-allyl cysteine and S-allyl mercaptocysteine. Also present are lipid soluble organosulfur compounds, carbohydrates, including fructans that are immuno-boosters, and micronutrients such as selenium and other antioxidants such as fructosyl, arginine and alixin.

AGE had been shown to enhance immunity and lower the risk of cardiovascular, cerebrovascular and neurodegenerative diseases, and cancer. Its rich anti oxidant content prevents cell damage and mutations by free radicals. AGE also protects against the free radical-producing side effects of drugs and radiation, including ultraviolet light from the sun and tanning machines.

Immune Vigor

Immunity is the secret to good health; it protects against invading organisms and prevents disease and aging. Without a strong immune system we are vulnerable to infectious bacteria and viruses that trigger mild as well as serious diseases, some leading to death.

Maintaining a powerful immune system helps prevent common colds and flu and fights inflammation that has a role in a number of diseases. The aim is to make sure the immune response wins the battle against disease-causing agents.

The human immune system includes lymphocytes and macrophages that attack and engulf foreign invaders; mast cells that regulate the inflammatory response and control allergies by releasing histamine; and natural killer (NK) cells that destroy tumor cells. The immune system also contains helper T cells that determine which types of immune responses the body will make to fight a particular pathogen. The helper cells direct other cells to perform various protective immune tasks.

Immunity, Enhanced

One of AGE’s roles in the body’s normal ability to suppress infectious diseases, block inflammation and kill cancer cells is a mechanism of programmed cell death called apoptosis. AGE was also reported to have antiallergic properties by blocking the release of histamines. AGE also suppresses inflammatory hormone-like substances called prostaglandins. AGE was found to inhibit cancer growth by enhancing the activity of various types of immune cells, and stimulating the number and activity of NK cells.

A random double-blind clinical trial in the Journal of Nutrition showed that AGE given to patients with inoperable co lorectal, liver or pancreatic cancer resulted in sig nifcant activity and numbers of the NK cells.

Another study, published in Oncology, AIDS patients, who had lower levels of NK cells as a result of the disease, showed that six weeks of supplementation by AGE (1800 mg/day) increased NK cells and helper T cells to levels found in healthy controls. The patients given AGE had an improvement of many health conditions including herpes virus infection, yeast infections and diarrhea. When compared to the effcacy of fresh garlic, the study showed that AGE was a more effective immune booster. NK activity was up by 140% with the fresh garlic preparation and by 160% with AGE capsules.

AGE is also found to protect against the fu. In a randomized, double-blind, placebo controlled study, investigators found that AGE reduced the prevalence of the common cold and fu symptoms by 61%. In addition, when AGE was given to people already suffering from colds and fu, it resulted in a 21% reduction in the number of symptoms.

The study was carried out as follows: Investigators gave 120 heal thy adults a daily dose of either 2.5 grams of AGE or a placebo. After 45 days, volunteers taking AGE had a signifcant increase in the number of immune cells compared to placebo. AGE enhanced the function of NK cells and gamma-delta T cells (a type of immune cell found in the intestinal tract). Both are fu and cold fighting immune cells.

Glutathione Booster

The study also found that the increase in immune function was due to the glutathione boosting effects of the water soluble organosulfur compounds such as S-allyl cysteine. Glutathione, a powerful antioxidant, protects disease fighting lymphocytes from oxidative damage cell death.

Taken before sunbathing, AGE protects against ultraviolet immunosuppression. Studies in Australia on human volunteers have shown that exposure to UV irradiation results in immunosuppression, which leads to an enhanced risk of skin cancer. In a preclinical study, using contact hypersensitivity as the immune response, the investigators found that immuno suppression induced by UVB radiation was reduced 19% by an in take of AGE as 4% of the total diet. These studies offer the possibility that AGE may also help protect humans against UV induced immunosuppression and have the potential to reduce the risk of skin cancer.

Blocks Inflammations

Prostaglandins are hormone-like substances called cytokines. They are linked to inflammation and pain; these cytokines accompany the destruction of tissues in inflammation.

Supplementation with AGE for 14 days has been shown to lower plasma and urine concentrations of the prostaglandin 8isoPGF by 29% and 37%, respectively in nonsmokers, and by 35% and 48% in smokers. The process is reversed if AGE supplementation is discontinued within 14 days after smoking cessation. The study shows that in order to reduce the risks of inflammation and maintain health, a continuous intake of AGE is required.

Stress Response

In a project using research models, the subjects were exposed to psychological stress, which resulted within four days in decreased spleen cells and weight and a reduction in NK cell activities as compared to non-stressed controls. AGE prevented the decreases in spleen weight and cells. NK activities in the subjects receiving AGE were almost the same as those in non-stressed subjects. The study showed that psychological stress impairs immune function and that AGE may help prevent psychologically induced damage.

Kyolic, an odorless garlic supplement made by Wakunaga of America, has been studied for its effects on human health with results published in more than 700 peer reviewed medical articles. Kyolic AGE is a po tent protector and enhancer of the immune system. A continuous daily intake has the potential to protect against a wide range of diseases in a safe way with no adverse side effects.

Carmia Borek Ph D.
Department of Public Heath and Community Medicine
Nutrition Infectious Disease Unit
Tufts University School of Medicine
Boston, MA 02111

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