60 Reversed to 20

De-aging pill

60 Reversed To 20, Health, Healthy Living Magazine

60 Reversed To 20, Health, Healthy Living Magazine

Researchers have discovered they can rewind the cause of aging in mice, reports the December 19 issue of Cell. Communications between nuclei and mitochondria in cells begin breaking down due to a deficiency in a chemical called NAD.

They explained that the nucleus and energy factory (mitochondrion) are of bacterial, genetically different origins and must talk with each other—sending chemicals and bioelectricity back and forth—to survive, and with the right added compound will thrive and enjoy well coordinated communication, which requires NAD.

“There’s clearly much more work to be done here, but if these results stand, then many aspects of aging may be reversible if caught early.” —David Sinclair, Harvard Medical School Professor of Genetics

When Nucleus and Mitochondria Communicate

“The aging process we discovered is like a married couple—when they are young, they communicate well, but over time, living in close quarters for many years, communication breaks down,” said Harvard Medical School Professor of Genetics David Sinclair, study senior author. “And just like with a couple, restoring communication solved the problem.”

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Mitochondrial energy factories in cells become inactive with age; lower activity leads to diabetes, cancer, Alzheimer’s and heart disease. One way the energy factories stay alert is to keep talking to their partner, the nucleus, to coordinate. The energy factory serves the nucleus and requires direction. Sinclair’s team studying sirtuins found the genes supply direction by blocking a chemical that breaks down NAD. Ana Gomes, a postdoctoral scientist in the Sinclair lab, has been working with mice with the SIRT1 gene removed. SIRT1 blocks HIF-1. Without sufficient NAD, SIRT1 loses its ability to keep tabs on HIF-1. When HIF-1 increases, cross-genome communication breaks down and the energy factory loses all its ability to make energy. Disease sets in. HIF-1 is also known to kick in when the body is depleted of oxygen, and high levels are associated with cancer. Although the mitochondria seem to suffer, so does the nucleus since it requires the energy factory. They need each other and they need communication.

A compound called resveratrol, available as a dietary supplement, becomes NAD in the body and restores communication, and with resumption of the cross talk the energy factor revs up again, according to the study. The restoration went further. Muscle examination of two-year old mice revealed those given resveratrol had no signs of insulin resistance, inflammation or muscle wasting. The tissues were akin to six-month-old mice. The transition is comparable to sixty human years reversible to 20.

“It’s certainly significant to find that a molecule that switches on in many cancers also switches on during aging,” Gomes told science media. “We’re starting to see now that the physiology of cancer is in certain ways similar to the physiology of aging. Perhaps this can explain why the greatest risk of cancer is age.”

References
Ana P. Gomes, Nathan L. Price, Alvin J.Y. Ling, Javid J. Moslehi, Magdalene K. Montgomery, Luis Rajman, James P. White, João S. Teodoro, Christiane D. Wrann, Basil P. Hubbard, Evi M. Mercken, Carlos M. Palmeira, Rafael de Cabo, Anabela P. Rolo, Nigel Turner, Eric L. Bell, David A. Sinclair. Declining NAD Induces a Pseudohypoxic State Disrupting Nuclear-Mitochondrial Communication during Aging. Cell, 2013; 155 (7): 1624 DOI: 10.1016/j.cell.2013.11.037
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