New Skin

Collagen Peptides Turn Back Aging Clock

New Skin - Healthy Living Magazine

New Skin - Healthy Living Magazine

Skin, hair, fingernails—all have one commonality: collagen. Collagen protein is the primary mortar between the bricks (cells) of skin, hair and nails, ligaments, tendons, blood vessels, digestive tract, heart, gallbladder, kidneys and bladder. Collagen peptides turn on fibroblasts, rebuilding skin shape and structure.

Collagen Deficiency Increases 1.5% A Year

Read: Scientists Woke Up Collagen-Related Gene In 80 Years Old

The sad aspect of the history of collagen is that the body’s own aging clock for this abundant compound peaks early. Deficiency begins at age 25 when production decreases an average of 1.5% per year. By age 60, over half of the body’s collagen is gone.

As collagen production falls, disrepair sets into the collagen fibers, the extra-cellular matrix that holds the cells together; one sees the visible signs of collagen deficiency: flaccid skin, wrinkles, moisture loss, pruning of the skin and appearing baked. In addition to the visible signs, ligaments that attach bones and tendons and muscles to bones are made up of collagen and begin to deteriorate.

High Nitrogen Strengthens Tissues

Supplementing with collagen supplies high-nitrogen amino acids glycine, proline and hydroxyproline whose peptides activate fibroblast cells to bundle and even repack collagen fibers and strengthen tissues

Skin Elasticity

Skin tightens. Wrinkles diminish. Moisture and elasticity return. In a study this year from Skin Pharmacology and Physiology, 69 women aged 35-55 were randomized to receive 2.5 or 5 grams of collagen (CH) or placebo once daily for 8 weeks with 23 subjects being allocated to each treatment group. Skin elasticity, skin moisture, water loss and skin roughness were measured before the first application and after 4 and 8 weeks. Skin elasticity (primary interest) was assessed. At the end of the study, skin elasticity in both CH dosage groups “showed a statistically significant improvement in comparison to placebo. After 4 weeks of follow-up treatment, a statistically significantly higher skin elasticity level was determined in elderly women. With regard to skin moisture and skin evaporation, a positive influence of CH treatment could be observed but data failed to reach statistical significance. No side effects were noted throughout the study.”

Procollagen I, Elastin And Fibrillin

In a study of a collagen peptide supplement on eye wrinkles the researchers found oral administration stimulated the body to produce procollagen type I, elastin and fibrillin. The ingestion of the specific collagen peptide led to less eye wrinkle volume and lasting higher content procollagen type I and elastin (18%) in the volunteers receiving the supplement. Oral intake “reduced skin wrinkles and had positive effects on dermal matrix synthesis.”

Vitamins & Collagen

Vitamins and minerals such as ascorbic acid, vitamin D, magnesium and zinc are needed to process collagen. Hyaluronic acid complements collagen supplements by pulling in moisture to rehydrate the skin.

Adding vitamin C (ascorbic acid) and carotenoids to collagen supplements increases the effect. The results of one study showed tissue growth and collagen synthesis were higher with both and they have “therapeutic potential” for skin repair.


Cynatine HNS, a dietary supplement with 70% soluble keratin protein, which makes up the skin’s outer layer, nails and hair, complements collagen. In the December 2013 International Journal of cosmetic Science, Cynatine HNS was tested among 50 women and found to reduce fine lines and wrinkles and redness from inflammation; firmness and elasticity increased; and higher antioxidant activity to prevent premature aging was detected in skin cells via superoxide dismutase and glutathione. In nails, the soluble keratin bound with them for strength, elasticity and moisture retention; in hair it reduced loss and increased strength and brightness. The combination of both collagen and keratin can be enhanced with amla berry, rich in vitamin C and necessary to collagen production.

Collagen Supplements

Collagen supplements used in the studies were enzymatically processed to split big molecules into bioavailable, bioactive peptides. Collagen that is split stimulates production of fibroblasts, according to a study published in cell and Tissue Research.

Adam M., et al. [Postmenopausal osteoporosis. Treatment with calcitonin and a diet rich in collagen proteins]. cas Lek cesk, 1996;31;135(3):74-78. Ahmad M, Ansari Mn, Alam A, Khan TH. Oral dose of citrus peel extracts promotes wound repair in diabetic rats. Pak J Biol Sci. 2013 Oct 15;16(20):1086-1094. Beer c, Wood S, Veghte RH. A randomized, double-blind, placebo-controlled clinical trial to investigate the effect of cynatine(®) HnS on skin characteristics. Int J cosmet Sci. 2013 Dec;35(6):608-612. doi: 10.1111/ics.12084. e-pub 2013 Sept 2. Moskowitz RW. Role of collagen hydrolysate in bone and joint disease. Semin Arthritis Rheum, 2000;30(2):87-99. Oesser S, Jürgen S. Stimulation of type II collagen biosynthesis and secretion in bovine chondrocytes cultured with degraded collagen. cell Tissue Res, 2003;311(3):393-399. Proksch e, Schunck M, Zague V, Segger D, Degwert J, Oesser S. Oral intake of specific bioactive collagen peptides reduces skin wrinkles and increases dermal matrix synthesis. Skin Pharmacol Physiol. 2014;27(3):113-119. doi: 10.1159/000355523. e-pub 2013 Dec 24. Proksch e, Segger D, Degwert J, Schunck M, Zague V, Oesser S. Oral supplementation of specific collagen peptides has beneficial effects on human skin physiology: a double-blind, placebo-controlled study. Skin Pharmacol Physiol. 2014;27(1):47-55. doi: 10.1159/000351376. e-pub 2013 Aug 14. Wang X., et al. Age-related changes in the collagen network and toughness of bone. Bone, 2002;31(1):1-7.
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