Anti-Clot Natto

Japanese food effective against blood clots and arteries’ hardening

Anti-Clot Natto. Healthy Living Magazine

Anti-Clot Natto. Healthy Living Magazine

In a clinical trial, the effects of a single dose of nattokinase (NK) on circulation in 12 healthy males was measured. Each received either a single-dose of 2,000 fibrinolytic units of nattokinase or placebo.

“A single-dose of NK administration appears enhancing fibrinolysis and anti-coagulation via several different pathways simultaneously.”

Japanese Anti-Clot

The fibrinolytic enzyme came to America as a dietary supplement in the 1990s when Hiroyuki Sumi, PhD, discovered nattokinase during his research into food-based anti-clotting agents. The traditional diet of the Japanese people contains fermented soy dishes such as tofu, tempeh and natto. In his test tube studies, Dr Sumi discovered that fibrin (the material that causes platelets to stick together and cause blood clots) completely dissolved within 18 hours when exposed to natto.

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Clinical Evidence

In a 1990 article in the journal Acta Haematology,Dr Sumi confirmed oral administration of natto capsules “produced a mild and frequent enhancement of the fibrinolytic activity in the plasma, as indicated by the fibrinolytic parameters, and the production of tissue plasminogen activator.” In the study, 12 healthy volunteers (six men and six women, aged 21 to 55) were given boiled soybeans (control group) once before breakfast or two enterically coated capsules containing 650 mg nattokinase per capsule three times a day after meals. Not only was the fibrinolytic activity significantly increased compared to persons in the control, its duration was maintained for as long as 8 hours. No untoward side effects were observed.

Lowers Blood Pressure

Giving nattokinase to high blood pressure patients had an almost immediate beneficial effect. After only 4 days, average diastolic value decreased from 173.8 mmHg to 154.8 mmHg and the systolic readings went down from 101.0 mmHg to 91.2 mmHg.

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Nattokinase And Artery Hardening

Not all the US doctors with whom we’ve spoken about natto like its taste but they like its effects on their patients’ circulation health. “In some ways, nattokinase is actually superior to conventional clot-dissolving drugs,” says Martin Milner, ND, president and medical director of the Center for Natural Medicine, professor of cardiovascular and pulmonary medicine at National College of Naturopathic Medicine, Portland Oregon and Bastyr University, Kenmore, Washington. “Tissue plasminogen activators (TPAs) like urokinase (the drug) are only effective when taken intravenously and often fail simply because a stroke or heart attack victim’s arteries have hardened beyond the point where they can be treated by any other clot-dissolving agent. Nattokinase, however, can help prevent that hardening with an oral dose of as little as 100 milligrams a day.”

Nattokinase is available as a dietary supplement. A high potency nattokinase product should supply approximately 4,000 fibrin degradation units per capsule.

Kurosawa Y, Nirengi S, Homma T, Esaki K, Ohta M, Clark JF, Hamaoka T. A single-dose of oral nattokinase potentiates thrombolysis and anticoagulation profiles. Sci Rep. 2015 Jun 25;5:11601. doi: 10.1038/srep11601. Maruyama, M. & Sumi, H. “Effect of natto diet on blood pressure.” Basic and Clinical Aspects of Japanese Traditional Food Natto II, 1-3, 1998. Milner, M. & Makise, K. “Natto and its active ingredient nattokinase: a potent and safe thrombolytic agent.” Alternative & Complementary Therapies, Jun 2002;8(3):157-164. Sumi, H., et al. “Enhancement of the fibrinolytic activity in plasma by oral administration of nattokinase.” Acta Haematol, 1990;84(3):139-143.
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