overactive bladder

Bathroom trapped? You Are Not Alone

Overactive Bladder Saga Pro

Overactive Bladder Saga Pro

17% women over 18 who have overactive bladders
16% men who have OB
20% adults over the age of 40 who have OB

Urinary incontinence, whether due to chronic bladder irritation, bladder weakness or bacteria, affects at least 25 million Americans. Most sufferers are women. One-third of women and men 30 to 70 years old experience symptoms of urinary incontinence.

The natural approach to treatment involves the clinically tested Icelandic herb, Angelica archangelica. This Angelica archangelica is not the same as Chinese angelica (Angelica sinensis), also known as dong quai.

Angelica archangelica contains a number of important compounds, including flavonoids such as isoquercitrin, polyphenols and polysaccharides, that are responsible for the plant’s effects.

The angelica extract taken from the leaf of the plant was tested in an eight-week, randomized, doubleblind, placebo-controlled study reported in the Scandinavian Journal of Urology; subjects suffering from nocturia—basically an overactive bladder at night—used Iceland’s Angelica archangelica, or a placebo. The subjects were aged 45 and older, which is when both sexes begin noticing urinary frequency.

Of course, one of the biggest problems with nocturia isn’t just the inconvenience of having to go to the bathroom; it’s the disruption of sleep, and the low energy and grogginess the next day.

There are a few things that are measured when researchers test those dealing with nocturia, including nocturnal urinary output and capacity. Bladder capacity decreases with age, and the bladder tissue gets weaker. This not only makes people feel a “need to go” but also makes them more prone to accidental “leaks” before they can find a bathroom or while they sleep.

During this study, three main parameters were measured: increase in bladder volume; reduction in nocturnal voids; increase in the duration of the first sleep period.

In the group with low bladder capacity, those taking the Angelica archangelica extract saw an increase of more than 300 percent in capacity. In the group reporting more than three nighttime urinations, the Arctic angelica extract enhanced sleep and significantly reduced nighttime bathroom visits.

Interestingly, among those men aged 70, it increased the duration of uninterrupted sleep (measured by time to first awakening) by 280 percent—almost three times that of placebo.

The direct action of Iceland’s Arctic Angelica archangelica improves bladder strength and reduces bladder nerve irritation, and is therefore appropriate for both sexes. The isoquercitrin content in Iceland’s Arctic angelica may be partly responsible for its effectiveness. Isoquercitrin can inhibit the activity of leukotrienes in the bladder and urethra that stimulate cell receptors, triggering overactive bladder contractions. The result is less urinary urgency and greater bladder capacity.

References“Urge Incontinence/Overactive Bladder”, from National Association for Continence. Available at: http://www. nafc.org/media/statistics/urge-incontinence-and-oab/. Accessed: March 25, 2013. Sigurdsson S, Geirsson G, Gudmundsdottir H, Egilsdottir PB, Gudbjarnason S. A parallel, randomized, double-blind, placebo-controlled study to investigate the effect of SagaPro on nocturia in men. Scand J Urol. 2013 Feb;47(1):26-32. Sigurdsson S, Gudbjarnason S. Inhibition of acetylcholinesterase by extracts and constituents from Angelica archangelica and Geranium sylvaticum. Z Naturforsch C. 2007 Sep-Oct;62(9-10):689-93. Sigurdsson S, Ogmundsdottir HM, Gudbjarnason S. Antiproliferative effect of Angelica archangelica fruits. Z Naturforsch C. 2004 Jul-Aug;59(7-8):523-7. Sigurdsson S, Ogmundsdottir HM, Gudbjarnason S. The cytotoxic effect of two chemotypes of essential oils from the fruits of Angelica archangelica L. Anticancer Res. 2005 May-Jun;25(3B):1877-80. Sigurdsson S, Ogmundsdottir HM, Hallgrimsson J, Gudbjarnason S. Antitumour activity of Angelica archangelica leaf extract. In Vivo. 2005 Jan-Feb;19(1):191-4.
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