Secret Cause of Aging

Leak in Guts

Secret Cause of Aging, Health, Healthy Living Magazine, Anthony Kleinsmith

Secret Cause of Aging, Health, Healthy Living Magazine, Anthony Kleinsmith

A major task of the intestine is to form a defensive barrier to prevent absorption of damaging substances from the external environment,” says Daniel Hollander, MD, of the Harbor-UCLA Research and Education Institute, and one of the nation’s leading experts on inflammatory bowel disease. This protective function of the intestinal mucosa is called permeability. Clinicians use inert, nonmetabolized sugars such as mannitol, rhamnose, or lactulose to measure the permeability barrier or the degree of leakiness of the intestinal mucosa.

Ample evidence indicates that permeability is increased in patients with Crohn’s disease, a type of inflammatory bowel disease (IBD), and in 10 to 20% of their clinically healthy relatives. Permeability is increased in celiac disease, another type of IBD, and by trauma, burns and use of nonsteroidal antiinflammatory drugs (NSAIDs) such as aspirin and ibuprofen.

Alcoholics and even infrequent drinkers should be concerned about leaky gut. Only 30% of alcoholics develop cirrhosis and new research suggests that the development of alcohol-induced liver injury is caused in part by a leaky gut, say researchers at the Department of Medicine (Division of Gastroenterology), Loyola University Medical School, Maywood, Illinois. Animal studies have shown that gutderived endotoxin is a leading factor in causing cirrhosis. Increased intestinal permeability has been shown to cause endotoxemia, (the presence of endotoxins in the blood which can lead to hemorrhage, shock and kidney damage) and, it is now believed, increased gastrointestinal permeability (leaky gut) contributing to alcoholic liver disease.

“Because only the alcoholics with chronic liver disease had increased intestinal permeability, we conclude that a ‘leaky’ gut may be a necessary co-factor for the development of chronic liver injury in heavy drinkers,” says Dr Hollander. Quality first-milking colostrum can address the risk for leaky gut. The immune factors in colostrum contain a number of antibodies that bind to invading microorganisms and hold them in check while they are destroyed by white blood cells.

Colostrum’s IgA antibodies attach themselves to invading microorganisms that are also able to stick to tissues, making it easier for white blood cells to attack the immobilized pathogen. Other substances present in colostrum aid the process of eliminating invading microorganisms. These include lactoferrin and transferrin, which capture the iron required by some bacteria to reproduce.

The growth factors in colostrum are also of substantial providence in leaky gut syndrome. It is well documented that growth hormone and the insulin-like growth factor superfamily of proteins, both of which are found in abundance in first-milking colostrum, aid in the proliferation of new cells.

Recent studies have documented how the use of bovine colostrum reduces excess permeability caused by the use of NSAIDs. The repair of the mucosal lining may also decrease the severity of some food allergies—especially those associated with undigested food particles leaking into the bloodstream.

Researchers at the Department of Gastroenterology, Imperial College School of Medicine, London, demonstrated colostrum’s relevance to users of painkillers. It is known that painkillers such as NSAIDs are effective analgesics and that some even reduce heart attack risk, but also cause gastrointestinal injury. These researchers note the dearth of preventive measures for people on painkillers.

“Bovine colostrum is a cheap, readily available source of growth factors, which reduces gastrointestinal injury in rats and mice,” they say. They examined whether spraydried, defatted colostrum could reduce the rise in gut permeability caused by NSAIDs.

Healthy male volunteers participated in a randomized crossover trial comparing changes in gut permeability before and after five days of indomethacin (a type of NSAID) therapy. In healthy volunteers, indomethacin caused a threefold increase in gut permeability, whereas no increase in permeability was seen when colostrum was co-administered. “These studies provide preliminary evidence that bovine colostrum, which is already available as an over-the-counter preparation, may provide a novel approach to the prevention of NSAID-induced gastrointestinal damage in humans.”

Repairing the intestinal damage caused by leaky gut syndrome can improve nutrient uptake. Leaky gut syndrome results in mineral deficiencies because the same inflammatory process that injures the mucosal lining damages carrier proteins. The lactoferrin and transferrin found in high quality colostrum serve as effective carrier proteins for iron and copper. Since the absorption of nutrients is of primary importance, resolution of leaky gut syndrome can have positive effects on many conditions.

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